100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
Show More
Indications of Othera 40
A medication called Othera 40 lowers the amount of acid your stomach produces. Heartburn, acid reflux, and issues with your food pipe are all treated with it. Stomach ulcers can also be prevented and treated with them. You should take Othera 40 as directed by your doctor.
Pharmacology
Esomeprazole is a proton pump inhibitor that inhibits the H+/K+ ATPase in the gastric parietal cell, suppressing gastric acid output. The first single optical isomer of a proton pump inhibitor, esomeprazole (S-isomer of omeprazole), provides superior acid control than racemic proton pump inhibitors.
Dosage & Administration
Inflammatory esophagitis
Interaction of Othera 40
Esomeprazole is extensively metabolized in the liver by CYP2C19 and CYP3A4. In vitro and in vivo studies have shown that esomeprazole is unlikely to inhibit CYP 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4. No clinically relevant interactions with drugs metabolized by these CYP enzymes are expected. Drug interaction studies have shown that esomeprazole has no clinically significant interaction with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin.
Esomeprazole may interfere with CYP2C19, the main metabolic enzyme of esomeprazole. The co-administration of 30 mg of esomeprazole and diazepam (a CYP2C19 substrate) resulted in a 45-fold increase in diazepam clearance. An increase in the plasma concentration of diazepam was observed 12 hours after ingestion. Esomeprazole works by inhibiting gastric acid secretion. Therefore, esomeprazole may affect the absorption of the drug, where gastric pH is an important determinant of bioavailability (such as ketoconazole, iron salts, and digoxin).
Concurrent use of oral contraceptives, diazepam, phenytoin, or quinidine does not seem to change the pharmacokinetic characteristics of esomeprazole.
Clarithromycin combination therapy: The combination of esomeprazole, clarithromycin, and amoxicillin increases the plasma concentrations of esomeprazole and 14-hydroxy clarithromycin.
Contraindications
Esomeprazole is contraindicated in patients with known hypersensitivity to any of the formulations.
Side Effects of Othera 40
Headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth are the most common side effects reported with Esomeprazole. When compared to short-term treatment, there is no difference in the categories of linked adverse events noticed with maintenance treatment up to 12 months.
Pregnancy & Lactation
Caution is advised by the manufacturer. Esomeprazole or its metabolites are not known to occur in human breast milk.
Precautions & Warnings
If the patient has severe liver failure and renal impairment, esomeprazole should be administered with caution. Proton pump inhibitors, such as Esomeprazole, may marginally increase the risk of hip, wrist, and spine fractures, especially when used for more than a year.
Storage Conditions
Store in a cool & dry place below 25ºC, and protect from light. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.